Mda & spherical vs. dj grh feat. donna marie / splash - illusion / blame the moon (remixes) - JuJa Italia

Cancer remains one of the most deadly diseases in the world, and the number of new cases increases each year [ 1 ]. Despite rapid advances in diagnostic procedures and treatments, the overall survival rate from cancer has not improved substantially over the past 30 years [ 2 ]. There is a need, therefore, to develop novel approaches for the accurate detection of early-stage of cancer and for targeted therapies based on the cancer-specific markers, which could lead to personalized medicine. Recent advances in nanomaterials have explored passive and active targeting strategies for enhancing intratumoral drug concentrations while limiting the unwanted toxicity to healthy tissue [ 3 - 5 ]. The targeted delivery of nanomaterials can overcome difficulties associated with conventional free anticancer drugs, including insolubility under aqueous conditions, rapid clearance, and a lack of selectivity, resulting in nonspecific toxicity toward normal cells and lower the dose of drugs delivered to the cancer cells [ 6 ]. Inorganic nanomaterials with a variety of unique intrinsic physical properties have attracted growing interest for use in biomedical imaging applications [ 7 , 8 ]. Among the imaging nanoprobes, magnetic iron oxide nanoparticles have been widely used as MRI contrast agents for cancer imaging, helping to provide anatomical details and furthermore real-time monitoring of the therapeutic response [ 9 , 10 ]. In this review, we first discuss selective targeting strategies using nanoparticles for achieving effective cancer detection and treatment; secondly, we discuss the various targeting moieties used as 'escort' molecules to specific tumor tissues; third, we discuss methods of conjugating the functional moieties to nanoparticles; finally, we discuss strategies for optimizing the nanoparticle surfaces for in vivo applications. We highlight the potential utility of magnetic nanoparticle-based theranostic systems, which thus far are shown to be suitable for clinical use.

MDA & Spherical vs. DJ GRH Feat. Donna Marie / Splash - Illusion / Blame The Moon (Remixes)MDA & Spherical vs. DJ GRH Feat. Donna Marie / Splash - Illusion / Blame The Moon (Remixes)